Effects of mode and carbohydrate on the granulocyte and monocyte response to intensive, prolonged exercise.


April 1998

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The influence of exercise mode and 6% carbohydrate (C) vs. placebo (P) beverage ingested on granulocyte and monocyte phagocytosis and oxidative burst activity (GMPOB) after prolonged and intensive exertion was measured in 10 triathletes.The triathletes acted as their own controls and ran or cycled for 2.5h at ~75% maximal O2 uptake, ingesting C or P (4 total sessions, random order, with beverages administered in double-blind fashion). During the 2.5-h exercise bouts, C or P (4 ml/kg) was ingested every 15 min. Five blood samples were collected (15 min before exercise, immediately after exercise, and 1.5, 3, and6 h after exercise). The pattern of change over time for GMPOB was significantly different between C and P conditions (P ≤ 0.05), with postexercise values lower during the C trials. Little difference was measured between running and cycling modes. C relative to P ingestion (but not exercise mode) was associated with higher plasma levels of glucose and insulin, lower plasma levels of cortisol and growth hormone, and lower blood neutrophil and monocyte cell counts. These data indicate that C vs. P ingestion is associated with higher plasma glucose levels, an attenuated cortisol response, and lower GMPOB.

J Appl Physiol. 84(4):1252-1259.

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