Upper limit for intestinal absorption of a dilute glucose solution in men at rest.
Duchman SM, Ryan AJ, Schedl HP, Summers RW, Bleiler TL, Gisolfi CV.
We studied gastric and intestinal function by gastric intubation/intestinal perfusion in six healthy male volunteers to evaluate optimal use of a 6% glucose-electrolyte (GES) solution. Gastric volume, residual volume, emptying rate, and secretion were measured for an initial 763 ± 19 ml gastric load of GES and at the beginning and end of four additional gastric loads (2.2 ml.kg-1; ~180 ml) given at 10-min intervals. The relatively high gastric (713 ± 58 ml) and residual (507 ± 26 ml) volumes maintained a high gastric emptying rate (19.5 ± 1.4 ml.min-1). Composition of the GES emptied into the duodenum was also measured in this first experiment. In a second experiment, this modified solution was infused (triple lumen tube) into the duodenum at a rate equal to gastric emptying rate, or at 38 or 77% greater rates. Absorption of water (11.3-12.9 ml.h-1.cm-1) and glucose 4.3-5.6 mmol.h-1.cm-1) were similar at all perfusion rates during the second experiment. We conclude that duodenojejunal segmental absorption rates of water and glucose produced by a rapid, sustained gastric emptying rate cannot be increased by delivering a greater load of glucose and water by intestinal perfusion.